|Calculated MW||21418 Da|
|Purification||Antiserum to human HP1Hsbeta was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to an epitope between amino acids 50-100 of human HP1Hsbeta (NP_006798.1).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Chromobox protein homolog 1, HP1Hsbeta, Heterochromatin protein 1 homolog beta, HP1 beta, Heterochromatin protein p25, M31, Modifier 1 protein, p25beta, CBX1, CBX|
|Target/Specificity||ABD11051 recognises human HP1Hsbeta (heterochromatin protein 1 homolog beta), a highly conserved nonhistone chromatin component and member of the HP1 family which are involved in heterochromatin formation, transcriptional activation and arrest, gene silencing and chromatin remodelling. HP1Hsbeta is one of three mammalian HP1 homologues which localize to centromeric heterochromatin and are characterized by an amino-terminal chromodomain, hinge region and a carboxy-terminal chromoshadow domain. HP1Hsbeta is a component of both pericentric and telomeric heterochromatin and can directly associate with EMSY, TIF1 (transcriptional intermediary factor 1), LBR (lamin B receptor) and CHAF1A (chromatin assembly factor 1, subunit A) via the chromoshadow domain, and with tri-methylated histone H3 lysine 9 via the chromodomain.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human HP1 beta Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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1. Lomberk, G. et al. (2006) The heterochromatin protein 1 family. Genome Biology 7: 228-235.
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