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>   home   >   Products   >   Primary Antibodies   >   Anti-BRCC36 Antibody    

Anti-BRCC36 Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC - Anti-BRCC36 Antibody  ABD11054
    Formalin fixed, paraffin embedded human brain stained with Rabbit anti Human BRCC36 following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
  • WB - Anti-BRCC36 Antibody  ABD11054
    Western blot analysis of whole cell lysate from MCF7 human breast adenocarcinoma cells probed with Rabbit anti Human BRCC36 at 0.5(A), 1(B) and 2(C) ug/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Additional Information
Other Species M,Rat
Purification Antiserum to human BRCC36 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen An 18 amino acid peptide from near the amino terminus of human BRCC36.
Shelf Life 18 months from date of despatch.
Target/Specificity AHP1465 recognises human BRCA1/BRCA2 complex subunit 36 (BRCC36), a 36.7kDa nuclear protein. BRCC36, together with BRCA1, BRCA2, Rad51 and BRCC45, forms a holoenzyme complex that possesses an ubiquitin E3 ligase activity. Studies have demonstrated that BRCC36 functions in enhancing cellular survival following DNA damage and that it is essential for ionizing radiation induced BRCA1 phosphorylation and nuclear foci formation. Research has shown that BRCC36 is aberrantly expressed in the majority of breast tumours indicating a potential role in the pathogenesis of the disease. It has been hypothesized that BRCC36 could be a potentially important target in the treatment of radiation-resistant breast tumours.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-BRCC36 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Dong, Y. et al. (2003) Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.
Mol. Cell 12:1087-99.2. Chen, X. et al. (2006) BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation.
Cancer Res. 66:5039-46.

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Cat# ABD11054
(40 western blots)
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