|Application ||WB, IHC-P|
|Calculated MW||49712 Da|
|Purification||Antiserum to human Carabin was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||A 17 amino acid peptide from near the amino terminus of human Carabin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Carabin, TBC1 domain family member 10C, TBC1D10C|
|Target/Specificity||ABD11055 recognises human Carabin, also known as TBC1 domain family member 10C (TBC1D10C), a 50 kDa protein belonging to the TBC1 domain family of proteins. Carabin differs from other members of the TBC1 domain protein family, which appear to play a role in the regulation of cell growth and differentiation. Studies demonstrate that Carabin is part of a negative regulatory loop for the intracellular TCR signalling pathway and acts as an inhibitor of the Ras signalling pathway. Carabin is also believed to mediate crosstalk between calcineurin and Ras. Carabin is most abundantly expressed in spleen and peripheral blood leucocytes. ABD11055 does not cross react with either TBC1D10A or TBC1D10B.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Carabin (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Pan, F., et al. (2007) Feedback inhibition of calcineurin and ras by a dual inhibitory protein carabin.Nature; 445:433-436.2. Weil, R., et al. (2006) Deciphering the pathway from the TCR to NF-kappaB.Cell Death Differ.; 13:826-833.3. Im, S.H., et al. (2004) Activation and deactivation of gene expression by Ca2+/calcineurin-NFAT-mediated signaling.Mol. Cells; 18:1-94. White, R.A., et al. (2000) The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, Bub2, and cdc16 maps to mouse chromosome 5 and human chromosome 4. Cytogenet. Cell Genet.; 89:272-275
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