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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Anti-CDKN2A Antibody    

Anti-CDKN2A Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-CDKN2A Antibody  ABD11056
    Western blot analysis of mouse colon lysate probed with Rabbit anti Human CDKN2A at 1(A) and 2(B) ug/ml
  • IHC-P - Anti-CDKN2A Antibody  ABD11056
    Formalin fixed, paraffin embedded human colon with Rabbit anti Mouse CDKN2A following heat mediated antigen retrieval using sodium citrate buffer, (pH6.0)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P42771
Other Accession Q8N726
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 16533 Da
Additional Information
Other Species M,Rat,H
Purification Antiserum to human CDKN2A was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen A 19 amino acid peptide located near the amino terminus of human CDKN2A.
Shelf Life 18 months from date of despatch.
Gene ID 1029
Other Names Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3, Cyclin-dependent kinase 4 inhibitor A, CDK4I, Multiple tumor suppressor 1, MTS-1, p16-INK4a, p16-INK4, p16INK4A, CDKN2A, CDKN2, MTS1
Target/Specificity ABD11056 recognises human cyclin-dependent kinase inhibitor 2A (CDKN2A), a 16kDa protein belonging to the CDKN2 cyclin dependent kinase inhibitor family. CDKN2A acts as a negative regulator of cell proliferation by interacting strongly with CDK4 and CDK6, thus inhibiting their ability to interact with cyclin D and to phosphorylate the retinoblastoma protein. CDKN2A is an important tumour suppressor and defects in its production results in tumour formation in a wide range of tissues, including cutaneous malignant melanoma and Li-Fraumeni syndrome.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-CDKN2A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Stone, S. et al. (1995) Complex structure and regulation of the P16 (MTS1) locus.
Cancer Res. 1995; 55:2988-2994. 2. Kamb, A. et al. (1994) Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus.
Nature Genet. 8:22-26.3. Kratzke, R.A. et al. (1995) Immunohistochemical analysis of the p16(INK4) cyclin-dependent kinase inhibitor in malignant mesothelioma.
J. Nat. Cancer Inst. 87:1870-18754. Stott.,F.J. et al. (1998) The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.
EMBO J. 1998; 17:5001-5014.

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Cat# ABD11056
(40 western blots)
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