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Anti-op18 (C-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC - Anti-op18 (C-Terminal) Antibody  ABD11058
    Formalin fixed, paraffin embedded human brain with Rabbit anti Human op18 following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
  • WB - Anti-op18 (C-Terminal) Antibody  ABD11058
    Western blot analysis of whole cell lysate from EL4 mouse lymphoblast cells probed with Rabbit anti Human op18 at 0.5(A), 1(B) and 2(C) ug/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P16949
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 17303 Da
Additional Information
Other Species M
Purification Antiserum to human op18 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen A 20 amino acid peptide located near the carboxy terminus of human op18.
Shelf Life 18 months from date of despatch.
Gene ID 3925
Other Names Stathmin, Leukemia-associated phosphoprotein p18, Metablastin, Oncoprotein 18, Op18, Phosphoprotein p19, pp19, Prosolin, Protein Pr22, pp17, STMN1, C1orf215, LAP18, OP18
Target/Specificity ABD11058 recognises Human op18, a 17.3kDa cytoplasmic protein belonging to the Strathmin family.Studies indicate that op18 may function as an intracellular relay by integrating several signalling pathways such as those involved in cell proliferation and differentiation. In addition, op18 is involved in the regulation of the microtubule filament system by destabilizing microtubules where it prevents assembly, and promotes disassembly of microtubules. Research also indicates that op18 is a potential target of the ASK1-p38 MAP kinase cascade suggesting that the ASK1-p38 cascade may regulate microtubule dynmamics through op18. Op18, while ubiquitously expressed in normal tissues, is highly expressed in a variety of cancers including leukaemia, prostate cancer, ovarian carcinoma and breast carcinoma. It has therefore been hypothesized that op18 may be a potential target for anti-cancer therapeutics.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-op18 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Mizumura, K., et al. (2006) Identification of op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade.
J. Cell Physiol.; 206:363-3702. Mistry, S.J., et al. (2002) Role of stathmin in the regulation of the mitotic spindle: potential applications in cancer therapy.
Mount Sinai J. Med.; 69:299-3043. Curmi, P.A., et al. (1999) Stathmin and its phosphoprotein family: general properties, biochemical and functional interaction with tubulin.
Cell Structure and Function; 24:345-3574. Belmont, L.D., et al. (1996) Identification of a protein that interacts with tubulin dimers and increases catastrophe rate of microtubules.
Cell; 84:623-631

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Cat# ABD11058
(40 western blots)
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