|Application ||WB, IHC-P|
|Calculated MW||17303 Da|
|Purification||Antiserum to human op18 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||A 20 amino acid peptide located near the carboxy terminus of human op18.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Stathmin, Leukemia-associated phosphoprotein p18, Metablastin, Oncoprotein 18, Op18, Phosphoprotein p19, pp19, Prosolin, Protein Pr22, pp17, STMN1, C1orf215, LAP18, OP18|
|Target/Specificity||ABD11058 recognises Human op18, a 17.3kDa cytoplasmic protein belonging to the Strathmin family.Studies indicate that op18 may function as an intracellular relay by integrating several signalling pathways such as those involved in cell proliferation and differentiation. In addition, op18 is involved in the regulation of the microtubule filament system by destabilizing microtubules where it prevents assembly, and promotes disassembly of microtubules. Research also indicates that op18 is a potential target of the ASK1-p38 MAP kinase cascade suggesting that the ASK1-p38 cascade may regulate microtubule dynmamics through op18. Op18, while ubiquitously expressed in normal tissues, is highly expressed in a variety of cancers including leukaemia, prostate cancer, ovarian carcinoma and breast carcinoma. It has therefore been hypothesized that op18 may be a potential target for anti-cancer therapeutics.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-op18 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Mizumura, K., et al. (2006) Identification of op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade.J. Cell Physiol.; 206:363-3702. Mistry, S.J., et al. (2002) Role of stathmin in the regulation of the mitotic spindle: potential applications in cancer therapy.Mount Sinai J. Med.; 69:299-3043. Curmi, P.A., et al. (1999) Stathmin and its phosphoprotein family: general properties, biochemical and functional interaction with tubulin. Cell Structure and Function; 24:345-3574. Belmont, L.D., et al. (1996) Identification of a protein that interacts with tubulin dimers and increases catastrophe rate of microtubules.Cell; 84:623-631
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