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Anti-ORAI1 (C-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-ORAI1 (C-Terminal) Antibody  ABD11059
    Western blot analysis of human ovary probed with Rabbit anti Human ORAI1 at 0.5(A), 1(B) and 2(C) ug/ml
  • IHC-P - Anti-ORAI1 (C-Terminal) Antibody  ABD11059
    Formalin fixed, paraffin embedded human spleen stained with Rabbit anti Human ORAI1 following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96D31
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 32668 Da
Additional Information
Other Species Rat,M
Purification Antiserum to human ORAI1 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen A 16 amino acid peptide from near the carboxy terminus of human ORAI1.
Shelf Life 18 months from date of despatch.
Gene ID 84876
Other Names Calcium release-activated calcium channel protein 1, Protein orai-1, Transmembrane protein 142A, ORAI1, CRACM1, TMEM142A
Target/Specificity ABD11059 recognises human ORAI1, also known as Transmembrane protein 142A (TMEM142A), a 32.7 kDa multi-pass membrane protein belonging to the ORAI family. Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI1 is a four- transmembrane spanning protein that is an essential component of CRAC. ORAI1 functions as a highly selective Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+sensor.Defective ORAI1 in humans is the cause of one form of hereditary severe combined immune deficiency (SCID), which results in ablated T-cell Ca2+entry.ABD11059 is not expected to cross react with either ORAI2 or ORAI3.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-ORAI1 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Feske, S., et al. (2006) A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.
Nature; 441:179-852. Soboloff, J., et al. (2006) Calcium signals mediated by STIM and Orai proteins – a new paradigm in inter-organelle communication.
Biochim. Biophys Acta.: 1763:1161-11683. Lewis, R.S. (2001) Calcium signaling mechanisms in T lymphocytes.
Annu. Rev. Immunol.; 19:497-521

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Cat# ABD11059
(40 western blots)
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