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Anti-ORAI3 (N-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • ICC - Anti-ORAI3 (N-Terminal) Antibody  ABD11060
    Immunocytochemical staining of A20 cells with Rabbit anti Human ORAI3
  • WB - Anti-ORAI3 (N-Terminal) Antibody  ABD11060
    Western blot analysis of whole cell lysate from A20 mouse B-cell lymphoma cells probed with Rabbit anti Human ORAI3 at 1(A), 2(B) and 4(C) ug/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BRQ5
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 31499 Da
Additional Information
Other Species Rat,M
Purification Antiserum to human ORAI3 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen A 15 amino acid peptide from near the amino terminus of human ORAI3.
Shelf Life 18 months from date of despatch.
Gene ID 93129
Other Names Protein orai-3, Transmembrane protein 142C, ORAI3, TMEM142C
Target/Specificity ABD11060 recognises human ORAI3, also known as Transmembrane protein 142C (TMEM142C), a 31.5 kDa multi-pass membrane protein belonging to the ORAI family. Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI3 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI3, along with ORAI1 and ORAI2, functions as a Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor. Studies indicate that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. ABD11060 is not expected to cross react with either ORAI1 or ORAI2.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-ORAI3 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Feske, S., et al. (2006) A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.
Nature; 441:179-852. Soboloff, J., et al. (2006) Calcium signals mediated by STIM and Orai proteins – a new paradigm in inter-organelle communication.
Biochim. Biophys.Acta: 1763:1161-11683. Mercer, J.C., et al. (2006) Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1.
J. Biol. Chem.; 281:24979-904. Lewis, R.S. (2001) Calcium signaling mechanisms in T lymphocytes.
Annu. Rev. Immunol.; 19:497-521

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Cat# ABD11060
(40 western blots)
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