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Anti-MCM2 Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-MCM2 Antibody  ABD11062
    Detection of human MCM2 in lysates of HeLa cells by Western blotting using Rabbit anti Human MCM2 . Also shown is a Coomassie stained gel from a CoIP experiment, identity of individual bands was determined by mass spectrometry
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49736
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 101896 Da
Additional Information
Other Species M,X
Purification Antiserum to human MCM2 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen Synthetic peptide corresponding to an epitope within amino acid residues 1-50 of human MCM2 (NP_0045117.2).
Shelf Life 18 months from date of despatch.
Gene ID 4171
Other Names DNA replication licensing factor MCM2,, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28, MCM2, BM28, CCNL1, CDCL1, KIAA0030
Target/Specificity ABD11062 specifically recognises the nuclear protein MCM2 (mini chromosome maintenance protein 2), a putative DNA replicative helicase and member of the MCM family, critical during the initiation of DNA replication.During the G1 phase of the cell cycle the MCM proteins, part of the pre-replicative complex which assembles at replication origins, undergo phosphorylation by kinases including cyclin dependent kinase (CDK) and Cdc7/Dbf4 (DDK). Studies have shown that the phosphorylation of MCM2 occurs on multiple sites, namely Ser27, Ser41, Ser53, Ser108 and Ser139 and that phosphorylation results in a conformational change of the complex and activation of the helicase activity.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-MCM2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Tsuji, T. et al. (2006) Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.
Mol. Biol. Cell 17: 4459-4472.1. Forsburg, S.L. (2004) Eukaryotic MCM proteins: Beyond replication initiation.
Microbiol. Mol. Biol. Rev. 68: 109-131.

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Cat# ABD11062
(40 western blots)
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