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>   home   >   Products   >   Primary Antibodies   >   Anti-Human MCM2 (pSer41) Antibody    

Anti-Human MCM2 (pSer41) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-Human MCM2 (pSer41) Antibody  ABD11063
    Detection of human phospho-MCM2 in whole cell lysates of HeLa cells either treated with alkaline phosphatase or untreated by Western blotting using Rabbit anti Human phospho-MCM2 . Membranes were subsequently re-probed with Rabbit anti Human MCM2 to confirm protein loading
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49736
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 101896 Da
Additional Information
Purification Antiserum to human MCM2 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen Synthetic phosphopeptide corresponding to an amino acid sequence within MCM2 which includes phosphorylated Ser41 (NP_0045117.2).
Shelf Life 18 months from date of despatch.
Gene ID 4171
Other Names DNA replication licensing factor MCM2,, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28, MCM2, BM28, CCNL1, CDCL1, KIAA0030
Target/Specificity ABD11063 specifically recognises the nuclear protein MCM2 (mini chromosome maintenance protein 2), when phosphorylated at Ser41.MCM2 is a putative DNA replicative helicase and member of the MCM family, critical during the initiation of DNA replication. During the G1 phase of the cell cycle the MCM proteins, part of the pre-replicative complex which assembles at replication origins, undergo phosphorylation by kinases including cyclin dependent kinase (CDK) and Cdc7/Dbf4 (DDK). Studies have shown that the phosphorylation of MCM2 occurs on multiple sites, namely Ser27, Ser41, Ser53, Ser108 and Ser139 and that phosphorylation results in a conformational change of the complex and activation of the helicase activity.
Preservative & Stabilisers 0.1% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human MCM2 (pSer41) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Tsuji, T. et al. (2006) Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.
Mol Biol. Cell 17: 4459-4472.1. Forsburg, S.L. (2004) Eukaryotic MCM proteins: Beyond replication initiation.
Microbiol. Mol. Biol. Rev. 68: 109-131.

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Cat# ABD11063
(40 western blots)
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