|Application ||WB, IP|
|Calculated MW||119700 Da|
|Purification||Antiserum to human MNAR was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to an epitope within amino acid residues 1000-1050 of human MNAR (AAN41255.1).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Proline-, glutamic acid- and leucine-rich protein 1, Modulator of non-genomic activity of estrogen receptor, Transcription factor HMX3, PELP1, HMX3, MNAR|
|Target/Specificity||ABD11064 specifically recognises MNAR (modulator of non-genomic activity of estrogen receptor), otherwise known as PELP1 (proline-, glutamic acid-, and leucine-rich protein-1), a phosphoprotein and novel steroid co-activator of the estrogen receptor (ER), which plays a role in E2-mediated cell cycle progression through interaction with the pRb pathway.MNAR acts as a transcriptional corepressor for nuclear receptors and can interact with chromatin-modifying complex components CBP (CRE-binding protein), histone deacetylase 2 and MTA (metastasis-associated protein)1. MNAR is a src SH2-binding protein which modulates the interaction of the ER to c-Src, leading to MAPK activation. Other properties of MNAR include interaction with PI3K, STAT3, and EGF, and studies have shown the deregulation of MNAR in breast tumours and endometrial cancers.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-MNAR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Vadlamudi, R.K. and Kumar, R. (2007) Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR.Nucl. Recept. Signal. 5:e004.
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