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Anti-MNAR Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-MNAR Antibody  ABD11064
    Detection of human MNAR in whole cell lysates from HeLa cells by immunoprecipitation using 3mcg/mg lysate of Rabbit anti Human MNAR . MNAR was also immunoprecipitated with an antibody recognising a different region within human MNAR. Human MNAR was also detected by Western Blotting in whole cell lysates of HeLa and 293T cells using Rabbit anti Human MNAR
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IZL8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 119700 Da
Additional Information
Other Species M
Purification Antiserum to human MNAR was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen Synthetic peptide corresponding to an epitope within amino acid residues 1000-1050 of human MNAR (AAN41255.1).
Shelf Life 18 months from date of despatch.
Gene ID 27043
Other Names Proline-, glutamic acid- and leucine-rich protein 1, Modulator of non-genomic activity of estrogen receptor, Transcription factor HMX3, PELP1, HMX3, MNAR
Target/Specificity ABD11064 specifically recognises MNAR (modulator of non-genomic activity of estrogen receptor), otherwise known as PELP1 (proline-, glutamic acid-, and leucine-rich protein-1), a phosphoprotein and novel steroid co-activator of the estrogen receptor (ER), which plays a role in E2-mediated cell cycle progression through interaction with the pRb pathway.MNAR acts as a transcriptional corepressor for nuclear receptors and can interact with chromatin-modifying complex components CBP (CRE-binding protein), histone deacetylase 2 and MTA (metastasis-associated protein)1. MNAR is a src SH2-binding protein which modulates the interaction of the ER to c-Src, leading to MAPK activation. Other properties of MNAR include interaction with PI3K, STAT3, and EGF, and studies have shown the deregulation of MNAR in breast tumours and endometrial cancers.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-MNAR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Vadlamudi, R.K. and Kumar, R. (2007) Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR.
Nucl. Recept. Signal. 5:e004.

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Cat# ABD11064
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