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Anti-Human MSH6 Antibody

Goat Anti-Human Polyclonal Antibody

  • WB - Anti-Human MSH6 Antibody  ABD11065
    Detection of Human MSH6 in HeLa (A.) and HCT116 3-6 (B.) cells by western Blotting (A.) and immunoprecipitation (B.) using Rabbit anti Human MSH6 . For immunoprecipitation (B.) MSH6 was subsequently detected using a mouse monoclonal anti MSH6 antibody in Western blotting
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Human
Host Goat
Clonality Polyclonal
Isotype Polyclonal IgG
Additional Information
Purification Antiserum to human MSH6 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen Synthetic peptide corresponding to an epitope within amino acid residues 350-400 of human MSH6 (UniProt: Q96CA5).
Shelf Life 12 months from date of reconstitution.
Target/Specificity Goat anti-Human MSH6 antibody recognizes human DNA mismatch repair protein (Msh6), also known as G/T mismatch-binding protein (GTBP) or MutS-alpha 160 kDa subunit,s. Msh6 is a nuclear protein and member of the MutS family of DNA mismatch-binding proteins, vital for DNA repair.MSH6 can form functional complexes with MSH2 which have been shown to recognise G/T nucleotide mismatches, as well as small nucleotide IDL (+T and +G) mismatches. Mutations in the MSH6 gene are known to hinder the repair of DNA mismatches, increasing an individual’s risk for developing cancer, as demonstrated in the autosomal inherited disease hereditary non-polyposis colorectal cancer (Ripaet al.2005).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃. DO NOT FREEZE.
PrecautionsAnti-Human MSH6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Acharya, S. et al. (1996) hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6.
P.N.A.S. 93: 13629-13634.

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Cat# ABD11065
(40 western blots)
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