|Application ||WB, IP|
|Purification||Antiserum to human MSH6 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to an epitope within amino acid residues 350-400 of human MSH6 (UniProt: Q96CA5).|
|Shelf Life||12 months from date of reconstitution.|
|Target/Specificity||Goat anti-Human MSH6 antibody recognizes human DNA mismatch repair protein (Msh6), also known as G/T mismatch-binding protein (GTBP) or MutS-alpha 160 kDa subunit,s. Msh6 is a nuclear protein and member of the MutS family of DNA mismatch-binding proteins, vital for DNA repair.MSH6 can form functional complexes with MSH2 which have been shown to recognise G/T nucleotide mismatches, as well as small nucleotide IDL (+T and +G) mismatches. Mutations in the MSH6 gene are known to hinder the repair of DNA mismatches, increasing an individual’s risk for developing cancer, as demonstrated in the autosomal inherited disease hereditary non-polyposis colorectal cancer (Ripaet al.2005).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃. DO NOT FREEZE.|
|Precautions||Anti-Human MSH6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Acharya, S. et al. (1996) hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. P.N.A.S. 93: 13629-13634.
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