|Application ||WB, IP|
|Calculated MW||69623 Da|
|Purification||Antiserum to human p73 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to an epitope within amino acid residues 1-62 of human p73 (GeneID 7161), found in the p73 isoforms alpha, beta, delta, epsilon, gamma, kappa and zeta.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tumor protein p73, p53-like transcription factor, p53-related protein, TP73, P73|
|Target/Specificity||ABD11066 specifically recognises human p73, a potential tumour suppressor protein and member of the p53 family which is expressed as several splice variants and acts as cell cycle regulator and inducer of apoptosis, sharing significant sequence homology and over-lapping functional properties with tumor suppressor p53.The abnormal expression of p73 and its various isoforms is linked with a variety of carcinomas including neuroblastoma, breast cancer, lung cancer, ovarian cancer, prostate cancer and renal cell carcinoma, and enhanced expression is apparent during the differentiation of myeloid leukaemic cells.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃. DO NOT FREEZE.|
|Precautions||Anti-Human p73 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Ceskova, P. et al. (2003) What we currently know about the structure and function of the p53 homologue – p73 protein: facts, hypotheses and expectations. Folia Biologica 49: 1-8.
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