|Other Accession||Q62829, Q64303|
|Calculated MW||60578 Da|
|Purification||Antisera to PAK 1/2/3 (pThr402) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns|
|Immunogen||Synthetic phosphopeptide corresponding to amino acid sequence surrounding phosphorylated Thr402 of rat PAK2|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Serine/threonine-protein kinase PAK 1, 188.8.131.52, Alpha-PAK, Protein kinase MUK2, p21-activated kinase 1, PAK-1, p68-PAK, Pak1|
|Target/Specificity||Rabbit anti-Rat PAK 1/2/3 (pThr402) antibody specifically recognizes rat p21-activated kinases (PAK) 1, 2 and 3 when phosphorylated at Thr402. PAKs are a highly conserved family of serine-threonine protein kinases that interact with small GTPases of the RHO family to re-organise the cytoskeleton. Alpha-PAK (PAK1) and beta-PAK (PAK3) are mostly expressed in the brain while gamma-PAK (PAK2) is expressed ubiquitously. In mammals, PAKs regulate the MAPK pathways and cytoskeletal organisation by increasing actin and tubulin polymerisation. PAKs also phosphorylate steroid receptors such as the estrogen and progesterone receptors. In humans the loss of function of PAK-3 is associated with nonsyndromic X-linked mental retardation. PAKs are phosphorylated on multiple residues, Autophosphorylation at Thr402 has been reported to be critical for activation of PAK kinases. It should be noted that Thr402 in PAK2 corresponds to Thr423 in PAK1.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 1% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Rat PAK 1/2/3 (pThr402) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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