Anti-Human Dopamine Transporter (Extracellular Loop 2) Antibody
Rabbit Anti-Human Polyclonal Antibody
|Application ||WB, IHC-F|
|Calculated MW||68495 Da|
|Purification||Antisera to human dopamine transporter (Extracellular loop 2) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Keyhole limpet haemocyanin conjugated synthetic peptide from the extracellular loop 2 region of human dopamine transporter.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Sodium-dependent dopamine transporter, DA transporter, DAT, Solute carrier family 6 member 3, SLC6A3, DAT1|
|Target/Specificity||ABD11073 recognises extracellular loop 2 of the human dopamine transporter (DAT). DAT is a Na+/Cl- dependent transport protein that is responsible for clearing synaptic dopamine by transporting it into neurons. The protein is implicated in a number of dopamine-related disorders such as attention deficit hyperactivity disorder, Parkinson’s disease, depression and drug abuse. DAT consists of 12 transmembrane domains connected by intra- and extracellular loops. The largest, extracellular loop 2, occurs between transmembrane domains 3 and 4 and contains N-linked carbohydrates and a putative disulfide bond. It is the site on the DAT protein that is most sensitive to proteolysis.|
|Preservative & Stabilisers||0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Dopamine Transporter (Extracellular Loop 2) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Gaffaney, J. D. and Vaughan, R. A. (2004) Uptake inhibitors but not substrates induce protease resistance in extracellular loop two of the dopamine transporter.Mol. Pharmacol. 65:692-701.
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