|Application ||IHC-P, E|
|Calculated MW||180429 Da|
|Purification||Antisera to human LRP6 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.|
|Immunogen||A synthetic peptide corresponding to amino acids 1546 - 1560 of human LRP6 – conjugated to KLH|
|Shelf Life||18 months from date of despatch.|
|Other Names||Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6|
|Target/Specificity||ABD11075 recognises human Low density lipoprotein receptor related-protein 6 (LRP6), a 180.4 kDa single pass type 1 membrane protein belonging to the LDLR family. LRP6 is an essential component of the Wnt/beta catenin signalling pathway where it is believed to act as a co-receptor with Frizzled for Wnt. It is a specific high affinity receptor for DKK1 and DKK2. LRP6 is implicated in a wide range of normal and disease processes connected with lipid metabolism. It is co-expressed with LDR5 during embryogenesis and in adult tissues. Defects in LRP6 cause autosomal dominant coronary artery disease type 2.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human LRP6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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