|Application ||WB, E|
|Calculated MW||60868 Da|
|Purification||Antiserum to human IRSp53 (CT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Peptide sequence C-HGDGSARTLAGR corresponding to the C-Terminal region of IRSp53 (NP_059345.1).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Brain-specific angiogenesis inhibitor 1-associated protein 2, BAI-associated protein 2, BAI1-associated protein 2, Protein BAP2, Fas ligand-associated factor 3, FLAF3, Insulin receptor substrate p53/p58, IRS-58, IRSp53/58, Insulin receptor substrate protein of 53 kDa, IRSp53, Insulin receptor substrate p53, BAIAP2|
|Target/Specificity||Goat anti-human IRSp53 (C terminal) polyclonal antibody specifically recognizes an epitope within the C-terminal (CT) region of isoform 2 of human IRSp53 (insulin receptor substrate p53), otherwise known as BAIAP2, a brain-enriched scaffolding protein which plays a key role in actin cytoskeletal reorganization and filopodia formation, acting as a signal transducing adaptor between membrane-bound Rho family GTPases Rho, Rac, and cdc42, and Rho family effectors mDia, WAVE2 and Mena.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human IRSp53 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Millard, T.H. et al. (2005) Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53.EMBO J. 24: 240-250.
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