|Application ||WB, E|
|Calculated MW||49903 Da|
|Purification||Antiserum to human PPAR Delta (CT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Peptide sequence CHPLLQEIYKDMY corresponding to the C-Terminal region of PPAR delta (NP_006229.1).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Peroxisome proliferator-activated receptor delta, PPAR-delta, NUCI, Nuclear hormone receptor 1, NUC1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta, PPARD, NR1C2, PPARB|
|Target/Specificity||ABD11083 specifically recognises an epitope within the C-terminal (CT) region of isoform 1 of human PPAR delta (peroxisome proliferator-activated receptor delta), a ubiquitously expressed member of the nuclear hormone receptor subfamily of transcription factors, which regulates peroxisome numbers and influences fatty acid metabolism. The transcriptional activity of PPAR delta depends upon its interaction with retinoid X receptor (RXR), which together bind to peroxisome proliferator-response elements (PPREs) within the promoter region of target genes, in the presence of cofactors. The interaction of PPAR delta with NCoR (nuclear receptor corepressor) and SMRT (silencing mediator for retinoid and thyroid hormone receptor), results in repression of PPAR delta transactivation.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human PPAR delta (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Krogsdam, A.M. et al. (2002) Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.Biochem. J. 363: 157-165.
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