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Anti-Human TRIM5 alpha (N-Terminal) Antibody

Goat Anti-Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9C035
Reactivity Human
Host Goat
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 56338 Da
Additional Information
Purification Antiserum to human TRIM5alpha (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen Peptide sequence ASGILVNVKEEVTC corresponding to the N-Terminal region of TRIM5 (NP_149023.1; NP_149083.1; NP_149084.1).
Shelf Life 18 months from date of despatch.
Gene ID 85363
Other Names Tripartite motif-containing protein 5, 6.3.2.-, RING finger protein 88, TRIM5, RNF88
Target/Specificity Goat anti-Human TRIM5 alpha antibody recognises an epitope within the N-terminal (NT) region of human TRIM5alpha, otherwise known as RNF88 (RING finger protein 88), a cytoplasmic protein and member of the TRIM/RBCC family, known to play a vital role in species-specific early defence against retrovirus infection.The association of TRIM5 with specific retroviral capsid sequences which determines the effectiveness of the defence against infection. For example, in Old World monkeys, TRIM5alpha specifically associates with HIV type 1 (HIV-1), whereas in humans TRIM5alpha is not effective against HIV-1, but can inhibit strains of the murine leukaemia virus (MLV).
Preservative & Stabilisers 0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin;
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human TRIM5 alpha (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Lee, K. and KewalRamani, V.N. (2004) In defense of the cell: TRIM5alpha interception of mammalian retroviruses.
P.N.A.S. 101: 10496-10497.

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Cat# ABD11084
(40 western blots)
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