|Calculated MW||40787 Da|
|Purification||Antiserum to human GRP15 (NT) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||A peptide corresponding to amino acids from near the amino terminus of human GPR15.|
|Shelf Life||18 months from date of despatch.|
|Other Names||G-protein coupled receptor 15, Brother of Bonzo, BoB, GPR15|
|Target/Specificity||Rabbit anti-Human GPR15 antibody recognizes Human G-protein coupled receptor 15 (GPR15) also known as Brother of Bonzo (BOB), a ~41 kDa multi-pass membrane protein. Human immunodeficiency virus (HIV) and related viruses require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four additional human molecules GPR15, STRL33, GPR1 and V28 have now been identified as HIV coreceptors. The genes encoding human and monkey GPR15/BOB have been cloned and research has demonstrated that his novel G protein-coupled receptor serves as co-receptor for simian immunodeficiency virus (SIV), and for strains of HIV-2 and M-tropic HIV-1.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human GPR15 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Heiber M., et al (1996) A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3.Genomics 32:462-5.2. Deng H.K., et al (1997) Expression cloning of new receptors used by simian and human immunodeficiency viruses.Nature 388:296-300.3. Farzan M., et al (1997) Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection.J. Exp. Med. 186:405-11.
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