|Application ||WB, IHC-P|
|Calculated MW||40396 Da|
|Purification||Antiserum to human CX3CR1 (NT) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||A peptide corresponding to amino acids 2 - 21 of human CX3CR1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||CX3C chemokine receptor 1, C-X3-C CKR-1, CX3CR1, Beta chemokine receptor-like 1, CMK-BRL-1, CMK-BRL1, Fractalkine receptor, G-protein coupled receptor 13, V28, CX3CR1, CMKBRL1, GPR13|
|Target/Specificity||ABD11089 recognises an epiptope within the N-terminal region (NT) of Human CX3CR1, a 40.4kDa seven trans-membrane protein. CX3CR1, known also as fractalkine receptor, is the receptor for CX3CL1 and acts as a co-receptor with CD4 for the HIV-1 envelope protein. It is expressed in a variety of human tissues and mediates leucocyte adhesion and migration.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CX3CR1 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Combadiere C., et al (1995) Cloning, chromosomal localization and RNA expression of a human beta chemokine receptor-like gene. DNA Cell Biol. 14:673-680.2. Combadiere C., et al (1998) Gene cloning, RNA distribution, and functional expression of mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine fractalkine. Biochem. Biophy. Res. Commun. 253:728-732.3. Combadiere C., et al (1998) Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1. J.Biol. Chem. 273:23799-804.4. Raport C.J., et al (1995) The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues.Gene 163:295-299.
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