|Application ||WB, IHC-F|
|Calculated MW||55344 Da|
|Purification||Antiserum to human FLIP gamma/delta (CT) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||A peptide corresponding to aa191-209 at the C-terminus of human FLIP delta/FLIPs form.|
|Shelf Life||18 months from date of despatch.|
|Other Names||CASP8 and FADD-like apoptosis regulator, Caspase homolog, CASH, Caspase-eight-related protein, Casper, Caspase-like apoptosis regulatory protein, CLARP, Cellular FLICE-like inhibitory protein, c-FLIP, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, I-FLICE, MACH-related inducer of toxicity, MRIT, Usurpin, CASP8 and FADD-like apoptosis regulator subunit p43, CASP8 and FADD-like apoptosis regulator subunit p12, CFLAR, CASH, CASP8AP1, CLARP, MRIT|
|Target/Specificity||Rabbit anti-FLIP Gamma/Delta antibody recognises the apoptosis related protein designated FLIP (FLICE inhibitory protein). FLIP interacts with the adaptor protein FADD, and with Caspase-8 (FLICE) and Caspase-10 (FLICE2) to inhibit apoptosis induced by death receptors including CD95, DR3, TRAIL-R and TNFR1. FLICE inhibitory proteins were initially identified in virus and human and were accordingly designated as v-FLIPs and c-FLIPs. Four spice variants of c-FLIP have been identified and are classified as FLIP alpha, beta, delta and gamma. Rabbit anti-FLIP Gamma/Delta antibody recognizes human and murine delta and gamma variants but not the alpha or beta, variants. FLIP is widely expressed in human tissues and a diverse range of cell lines.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-FLIP Gamma/Delta (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Thome M., et al (1997) Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors.Nature 386:517-521.2. Irmler M., et al (1997) Inhibition of death receptor signals by cellular FLIP.Nature 388:190-195.3. Shu H.B., et al (1997) Casper is a FADD- and caspase-related inducer of apoptosis.Immunity 6:751-763.4. Hu S., et al (1997) I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis.J. Biol. Chem. 272:17255-17257.
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