|Application ||WB, E|
|Calculated MW||58282 Da|
|Purification||Antisera to human FTO were raised by repeated immunisations of rabbits with highly purified antigen.|
|Immunogen||Two peptides designed to the N- and C-terminal regions of the human FTO gene.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Alpha-ketoglutarate-dependent dioxygenase FTO, 1.14.11.-, Fat mass and obesity-associated protein, FTO, KIAA1752|
|Target/Specificity||ABD11094 recognises human FTO, otherwise known as fat mass and obesity-associated protein, a 60kDa protein expressed ubiquitously with particularly high levels in the adrenal glands and brain. The gene was named FTO because a deletion in it resulted in fused toes and other abnormalities in mice. Since then, some correlation has been shown between carriers of the gene and obesity as well as an increased risk of Type 2 diabetes.The precise function of the gene is unknown but it shows homology with the enzyme AlkB, which oxidatively demethylates DNA. FTO gene expression has been shown to be highly upregulated in rats after food deprivation. A negative correlation with the expression of orexin peptide, which is involved in the stimulation of food intake, has also been found.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human FTO Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
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