|Application ||WB, IHC-F|
|Calculated MW||21097 Da|
|Purification||Antiserum to human Precerebellin was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||A peptide corresponding to an 16 amino acid sequence from near the carboxy terminus of human Precerebellin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Cerebellin-1, Precerebellin, Cerebellin, CER, [des-Ser1]-cerebellin, CBLN1|
|Target/Specificity||ABD11105 recognises human Precerebellin also known as Cerebellin-1, CBLN1 or Cerebellin precursor, a secreted membrane protein with a predicted molecular weight of 21kDa.Precerebellin is required for synapse integrity and synaptic plasticity and for the ER export and secretion of CBLN3. Precerebellin exerts neuromodulatory functions including directly stimulating norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release. Research indicates that Precerebellin may also be involved in a wider range of functions than have been so far demonstrated.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Cerebellin-1 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Albertin G., et al (2000) Cerebellin stimulates the secretory activity of the rat adrenal gland: in vitro and in vivo studies.Neuropeptides 34:7-112. Mazzocchi G., et al (1999) Cerebellin enhances in vitro secretory activity of human adrenal gland. J. Clin. Endocrinol. Metab. 84:632-5.3. Urade Y., et al (1991) Precerebellin is a cerebellum-specific protein with similarity to the globular component C1q B chain.PNAS 88:1069-73
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