|Application ||WB, IF, E|
|Calculated MW||380110 Da|
|Purification||Antiserum to human West Nile Virus core protein was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||A peptide corresponding to an 15 amino acid sequence from near the carboxy terminus of West Nile Virus core protein.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Genome polyprotein, Peptide 2k, Capsid protein C, Core protein, prM, Peptide pr, Small envelope protein M, Matrix protein, Envelope protein E, Non-structural protein 1, NS1, Non-structural protein 2A, NS2A, Serine protease subunit NS2B, Flavivirin protease NS2B regulatory subunit, Non-structural protein 2B, Serine protease NS3, 220.127.116.11, 18.104.22.168, 22.214.171.124, Flavivirin protease NS3 catalytic subunit, Non-structural protein 3, Non-structural protein 4A, NS4A, Non-structural protein 4B, NS4B, RNA-directed RNA polymerase NS5, 126.96.36.199, 188.8.131.52, 184.108.40.206, NS5, POLG|
|Target/Specificity||Rabbit anti-West Nile Virus antibody recognizes the ~14 kDa core protein of West Nile Virus (WNV). WNV belongs to the Flaviviridae family which includes closely viruses such as Dengue fever, Yellow fever and Tick borne encephalitis. West Nile Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope containing envelope and matrix proteins. Research indicates that the viral core protein contributes to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway.West Nile Virus is spread by mosquitos and is believed to have originated in the West Nile region of Africa but has now spread to Europe, Asia and America where it has become a significant disease affecting human and domestic animal health.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-WNV Core Protein (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Gould, L.H., et al (2004) West Nile virus: a growing concern.J.Clin. Invest. 113:1102-11072. Chu, J.J., et al (2005) Inhibition of West Nile virus entry by using a recombinant domain III from the envelope glycoprotein. J. Gen. Virol. 86:405-123. Chu, J.J., et al (2004) Interaction of West Nile virus with a v ß 3 integrin mediates virus entry into cells.J. Biol. Chem. 2004; 279:54533-41.4. Yang, J.S., et al (2002) Induction of inflammation by West Nile Virus capsid through the caspase-9 apoptotic pathway.Emerg. Infect. Dis. 8:1379-84.
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