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Anti-WNV Core Protein (C-Terminal) Antibody

Rabbit Anti-Viral Polyclonal Antibody

  • WB - Anti-WNV Core Protein (C-Terminal) Antibody  ABD11108
    Western blot analysis of WNV transfected (B) and untransfected (A) Hela cell lysates probed with Rabbit anti WNV core protein
  • IF - Anti-WNV Core Protein (C-Terminal) Antibody  ABD11108
    Immunofluorescent staining of WNV transfected Vero cells with Rabbit anti WNV core protein
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P06935
Reactivity Virus
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 380110 Da
Additional Information
Purification Antiserum to human West Nile Virus core protein was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen A peptide corresponding to an 15 amino acid sequence from near the carboxy terminus of West Nile Virus core protein.
Shelf Life 18 months from date of despatch.
Gene ID 912267
Other Names Genome polyprotein, Peptide 2k, Capsid protein C, Core protein, prM, Peptide pr, Small envelope protein M, Matrix protein, Envelope protein E, Non-structural protein 1, NS1, Non-structural protein 2A, NS2A, Serine protease subunit NS2B, Flavivirin protease NS2B regulatory subunit, Non-structural protein 2B, Serine protease NS3,,,, Flavivirin protease NS3 catalytic subunit, Non-structural protein 3, Non-structural protein 4A, NS4A, Non-structural protein 4B, NS4B, RNA-directed RNA polymerase NS5,,,, NS5, POLG
Target/Specificity Rabbit anti-West Nile Virus antibody recognizes the ~14 kDa core protein of West Nile Virus (WNV). WNV belongs to the Flaviviridae family which includes closely viruses such as Dengue fever, Yellow fever and Tick borne encephalitis. West Nile Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope containing envelope and matrix proteins. Research indicates that the viral core protein contributes to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway.West Nile Virus is spread by mosquitos and is believed to have originated in the West Nile region of Africa but has now spread to Europe, Asia and America where it has become a significant disease affecting human and domestic animal health.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-WNV Core Protein (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Gould, L.H., et al (2004) West Nile virus: a growing concern.
J.Clin. Invest. 113:1102-11072. Chu, J.J., et al (2005) Inhibition of West Nile virus entry by using a recombinant domain III from the envelope glycoprotein.
J. Gen. Virol. 86:405-123. Chu, J.J., et al (2004) Interaction of West Nile virus with a v ß 3 integrin mediates virus entry into cells.
J. Biol. Chem. 2004; 279:54533-41.4. Yang, J.S., et al (2002) Induction of inflammation by West Nile Virus capsid through the caspase-9 apoptotic pathway.
Emerg. Infect. Dis. 8:1379-84.

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Cat# ABD11108
(40 western blots)
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