|Application ||WB, IHC-P|
|Calculated MW||26253 Da|
|Purification||Antisera to human DRAM were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.|
|Immunogen||A peptide corresponding to a 16 amino acid sequence from near the carboxy terminus of Human DRAM.|
|Shelf Life||18 months from date of despatch.|
|Other Names||DNA damage-regulated autophagy modulator protein 1, Damage-regulated autophagy modulator, DRAM1, DRAM|
|Target/Specificity||Rabbit anti-DRAM (C-terminal) antibody recognizes human DRAM, a lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. DRAM is significantly down-regulated in tumor cell lines by methylation-dependent transcriptional silencing.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-DRAM (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Crighton D, et al. (2007) DRAM links autophagy to p53 and programmed cell death. Autophagy 3:72-42. Crighton D, et al (2006) DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 126:121-34. 3. Gozuacik D., et al (2004) Autophagy as a cell death and tumor suppressor mechanism. . Oncogene 23:2891-906
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