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Anti-Human CD234 (N-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-Human CD234 (N-Terminal) Antibody  ABD11118
    Western blot analysis of whole cell lysate from PC-3 human prostate cancer cells probed with Rabbit anti Human CD234 at 0.5(A), 1(B) and 2(C) ug/ml
  • IHC - Anti-Human CD234 (N-Terminal) Antibody  ABD11118
    Imunohistochemical staining of human brain with Rabbit anti Human CD234
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16570
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 35553 Da
Additional Information
Purification Antisera to Human CD234 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
Immunogen A peptide corresponding to a 18 amino acid sequence from near the amino terminus of Human CD234.
Shelf Life 18 months from date of despatch.
Gene ID 2532
Other Names Atypical chemokine receptor 1, Duffy antigen/chemokine receptor, Fy glycoprotein, GpFy, Glycoprotein D, Plasmodium vivax receptor, CD234, ACKR1, DARC, FY, GPD
Target/Specificity Rabbit anti-Human CD234 antibody detects CD234, also known as DARC, a multi-pass membrane protein belonging to the G protein coupled Duffy family. CD234 is a non-specific receptor for a number of cytokines including IL-8, GRO, RANTES, MCP-1 and TARC.CD234 also functions as the receptor for the malaria parasites Plasmodium vivax and P. knowlesi. CD234 is also responsible for the Duffy blood group system where a substitution at position 42 of either Gly-42 or Asp-42 results in Fy(A) or Fy(B). CD234 is present in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along post capillary venules throughout the body, except in the adult liver. Erythroid cells and post capillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium. It has been demonstrated that CD234 exists in multiple isoforms.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD234 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Gardner, L. et al. (2004) The human Duffy antigen binds selected inflammatory but not homeostatic chemokines.
Biochem Biophys Res Commun. 321 (2): 306-12.2. Chaudhuri, A. et al. (1993) Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite.
Proc Natl Acad Sci U S A. 90 (22): 10793-7.3. Gil, M.L. et al. (1992) A member of the tetra spans transmembrane protein superfamily is recognized by a monoclonal antibody raised against an HLA class I-deficient, lymphokine-activated killer-susceptible, B lymphocyte line. Cloning and preliminary functional studies.
J Immunol. 148 (9): 2826-33.

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Cat# ABD11118
(40 western blots)
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