|Application ||IHC-P, FC, E|
|Calculated MW||42165 Da|
|Purification||Antiserum to human CD262 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide APQQKRSSPSEGLCPPGHHISEDGRDC corresponding to amino acids 68-94 of the extracellular domain of human CD262.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, MK, CD262, Tnfrsf10b, Dr5, Killer|
|Target/Specificity||Goat anti-Human CD262 antibody recognizes CD262, otherwise known as DR5/TRAIL-R2, a broadly expressed death domain containing receptor and member of the TNF-receptor superfamily, which acts as a mediator for CD253/TRAIL induced apoptosis in a variety of tumor and transformed cells, but not in normal cells. Expression of CD262 is regulated by tumor suppressor p53, and CD262 is highly expressed by tumour cell lines. Studies suggest that the death domain containing adaptor protein FADD, is required for CD262-mediated apoptosis, and that FADD recruits caspase-8 to the activated receptor.Goat anti-Human CD262 antibody is suitable for use in immunocytochemistry.|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at -20℃ only.|
|Precautions||Anti-Human CD262 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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