|Application ||WB, IHC-P, E|
|Calculated MW||39334 Da|
|Purification||Antiserum to human CD184 / CXCR4 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide TEEMGSGDYDSMKEPCFREENANFNKC corresponding to amino acids 17-43 within the N-terminal region of human CD184 / CXCR4.|
|Shelf Life||18 months from date of despatch.|
|Other Names||C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, Fusin, Leukocyte-derived seven transmembrane domain receptor, LESTR, Stromal cell-derived factor 1 receptor, SDF-1 receptor, CD184, Cxcr4, Cmkar4|
|Target/Specificity||Goat anti-Human CD184 / CXCR4 antibody recognises an epitope within the N-terminal (NT) region of human CD184, otherwise known as CXCR4 (C-X-C chemokine receptor type 4), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, ubiquitously expressed in blood and tissue cells, which acts as a specific receptor for the chemokine SDF-1 (Stromal cell-derived factor 1). Interaction of CD184 with SDF-1 mediates the chemotaxis of progenitor and mature blood cells, and is critical for B- lymphopoiesis and myelopoiesis. CD184 is a major co-receptor for infection by T-cell tropic strains of HIV1, and also a primary receptor for some HIV2 isolates. This Goat anti-Human CD184 / CXCR4 antibody is reported as being suitable for use in immunofluorescence studies.|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3); 0.1% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD184 / CXCR4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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