|Calculated MW||17923 Da|
|Purification||Antiserum to human IL-21 (CT) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide CDSYEKKPPKEFLERFKSLLQKMIHQHLS corresponding to amino acids 125-153 within the C-terminal region of human IL-21.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Interleukin-21, IL-21, Za11, IL21|
|Target/Specificity||Rabbit anti-Human Interleukin-21 antibody recognizes human interleukin-21, also known as IL-21 or Za11. IL-21 is a 155 amino acid ~18 kDa cytokine secreted by activated CD4+ve cells. Rabbit anti-Human Interleukin-21 antibody recognizes an epitope within the C-terminal (CT) region of human interleukin-21 (IL-21), a potent immunoregulatory cytokine and member of the IL-15/IL-21 family.IL-21 enhances the proliferation/differentiation of stimulated B-cells, the proliferation of bone marrow progenitor cells, and increases the activity of NK cells and disease-specific CD8+ T-cells. IL-21 signals through binding to the specific type I cytokine receptor IL-21R, coupled with the common cytokine receptor g chain (gc), initiating the activation of the JAK/STAT signalling pathway. Rabbit anti-Human Interleukin-21 antibody is suitable for use in immunocytochemistry on human spleen cells.|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3); 0.1% Bovine Serum Albumin;|
|Storage||Store at -20℃ only.|
|Precautions||Anti-Human Interleukin-21 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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