|Application ||WB, IHC-P|
|Calculated MW||71722 Da|
|Purification||Antiserum to human IL-23R (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide CQPRKLHFYKNGIKERFQITRINKTTARL corresponding to amino acids 59-87 within the N-terminal region of human IL-23 receptor.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Interleukin-23 receptor, IL-23 receptor, IL-23R, IL23R|
|Target/Specificity||Goat anti-Human Interleukin-23 receptor antibody recognizes the human interleukin-23 receptor (IL-23R). The interleukin-23 receptor is 629 amino acid ~72kDa single pass type I transmembrane glycoprotein belonging to the type I cytokine receptor family and posessing two fibronectin type III domains. Multiple potential isoforms formed by alternative splicing are described. Goat anti-Human Interleukin-23 receptor antibody recognizes an epitope within the N-terminal (NT) region of Interleukin-23 receptor (IL-23R), precsent in isoforms 1, 3 and 4 (UniProt: Q5VWK5), the anytibody is not expected to recognize other truncated forms of the receptor lacking the immunogen sequence. IL-23R is a mediator of T-cell, NK cell, and possibly macrophage/myeloid cell, stimulation acting as the receptor for IL-23, by association with the beta component of IL-12R and is thought to signal through activation of the JAK-STAT signalling pathway. Genetic variation in IL23R is associated with inflammatory bowel disease type 17 (Kistneret al.2006) and susceptibility to the ulcerative and inflammatory psoriasis (Hüffmeieret al.2009).Goat anti-Human Interleukin-23 receptor antibody is reported as suitable for use in immunocytochemistry on acetone fixed cells and has been used successfully for the immunohistochemical localization of IL-23R in formalin fixed, paraffin embedded human tissues. .|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3); 0.1% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Interleukin-23 Receptor (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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