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Anti-Human Interleukin-23 Receptor (N-Terminal) Antibody

Goat Anti-Human Polyclonal Antibody

  • IHC - Anti-Human Interleukin-23 Receptor (N-Terminal) Antibody  ABD11158
    Paraffin embedded human spleen stained with Goat anti human IL-23 Receptor
  • IHC-P - Anti-Human Interleukin-23 Receptor (N-Terminal) Antibody  ABD11158
    Paraffin embedded mouse spleen stained with Goat anti human IL-23 Receptor
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5VWK5
Other Accession Q8K4B4
Reactivity Human
Host Goat
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 71722 Da
Additional Information
Other Species M
Purification Antiserum to human IL-23R (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Immunogen Synthetic peptide CQPRKLHFYKNGIKERFQITRINKTTARL corresponding to amino acids 59-87 within the N-terminal region of human IL-23 receptor.
Shelf Life 18 months from date of despatch.
Gene ID 149233
Other Names Interleukin-23 receptor, IL-23 receptor, IL-23R, IL23R
Target/Specificity Goat anti-Human Interleukin-23 receptor antibody recognizes the human interleukin-23 receptor (IL-23R). The interleukin-23 receptor is 629 amino acid ~72kDa single pass type I transmembrane glycoprotein belonging to the type I cytokine receptor family and posessing two fibronectin type III domains. Multiple potential isoforms formed by alternative splicing are described. Goat anti-Human Interleukin-23 receptor antibody recognizes an epitope within the N-terminal (NT) region of Interleukin-23 receptor (IL-23R), precsent in isoforms 1, 3 and 4 (UniProt: Q5VWK5), the anytibody is not expected to recognize other truncated forms of the receptor lacking the immunogen sequence. IL-23R is a mediator of T-cell, NK cell, and possibly macrophage/myeloid cell, stimulation acting as the receptor for IL-23, by association with the beta component of IL-12R and is thought to signal through activation of the JAK-STAT signalling pathway. Genetic variation in IL23R is associated with inflammatory bowel disease type 17 (Kistneret al.2006) and susceptibility to the ulcerative and inflammatory psoriasis (Hüffmeieret al.2009).Goat anti-Human Interleukin-23 receptor antibody is reported as suitable for use in immunocytochemistry on acetone fixed cells and has been used successfully for the immunohistochemical localization of IL-23R in formalin fixed, paraffin embedded human tissues. .
Preservative & Stabilisers 0.1% Sodium Azide (NaN3); 0.1% Bovine Serum Albumin;
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Interleukin-23 Receptor (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Cat# ABD11158
(40 western blots)
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