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Anti-Human CD284 (N-Terminal) Antibody
Goat Anti-Human Polyclonal Antibody
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Application 
| WB, IHC-P |
|---|---|
| Primary Accession | O00206 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | Polyclonal IgG |
| Calculated MW | 95680 Da |
| Other Species | M,Rat |
|---|---|
| Purification | Antiserum to human CD284 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography. |
| Immunogen | Synthetic peptide LIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYC corresponding to amino acids 161-192 within the N-terminal region of Human CD284. |
| Shelf Life | 18 months from date of despatch. |
| Gene ID | 7099 |
| Other Names | Toll-like receptor 4, hToll, CD284, TLR4 |
| Target/Specificity | Goat anti-Human CD284 antibody recognizes the human Toll-like receptor 4, also known as CD284, hToll or TLR4. CD284 is an 839 amino acid ~96 kDa single pass type I transmembrane glycoprotein expressed by peripheral blood leucocytes, activated T cells, monocytes, macrophages, dendritic cells, granulocytes and endothelial cells. CD284 plays a primary role in the activation of innate immunity (UniProt: O00206).Goat anti-Human CD284 antibody recognizes an epitope within the N-terminal (NT) region of CD284, a highly conserved member of the toll-like receptor family which acts as a receptor for bacterial lipopolysaccharides (LPS) in co-operation with CD14 and MD2 (LY96), resulting in the activation of the MyD88-dependent and MyD88-independent (TRIF-dependent) signalling pathways and the production of inflammatory cytokines. LPS-activated CD284 can also induce dendritic cell maturation via TRIF-dependent signaling.Goat anti-Human CD284 antibody is reported to be suitable for use in immunocytochemistry on acetone fixed cells. |
| Preservative & Stabilisers | 0.1% Sodium Azide (NaN3); 0.1% Bovine Serum Albumin; |
| Storage | Store at +4℃ or at -20 ℃. |
| Precautions | Anti-Human CD284 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
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Cat# ABD11159
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