|Application ||WB, IHC-P|
|Calculated MW||54007 Da|
|Purification||Antiserum to MMP-1 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||A synthetic peptide corresponding to the N-terminus of the pro form of human MMP1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Interstitial collagenase, 220.127.116.11, Fibroblast collagenase, Matrix metalloproteinase-1, MMP-1, 22 kDa interstitial collagenase, 27 kDa interstitial collagenase, MMP1, CLG|
|Target/Specificity||Rabbit anti-human MMP-1 antibody recognises human matrix metalloproteinase 1. The MMP’s are zinc-dependent endopeptidases responsible for degrading the extracellular matrix. They are also involved in cell proliferation, migration, differentiation and apoptosis. Most MMP’s are synthesised as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active. Their expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis. MMP-1 is one of the collagenases, capable of degrading collagens I, II and III, all main components of the interstitial stroma. It is overexpressed in invasive melanoma, colorectal and esophageal cancers. It has also been implicated in arthritis and might influence atherosclerotic lesion formation. It might also be involved in the repair processes of the heart after myocardial infarction.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 0.1% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human MMP-1 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Ierusalimsky, V.N. et al. (2013) Expression of the type 1 metalloproteinase in the rat hippocampus after the intracerebroventricular injection of ß-amyloid peptide (25-35).Acta Neurobiol Exp (Wars). 73: 571-8.
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