|Application ||IHC-P, E|
|Calculated MW||54151 Da|
|Purification||Antiserum to MMP-10 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||A synthetic peptide corresponding to the Hinge region of of human MMP10.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Stromelysin-2, SL-2, 22.214.171.124, Matrix metalloproteinase-10, MMP-10, Transin-2, MMP10, STMY2|
|Target/Specificity||Rabbit anti-Human MMP-10 antibody recognizes human matrix metalloproteinase 10 (MMP-10) also known as Stromelysin-2.This antibody recognizes both the pro and active form of MMP-10.The MMP’s are zinc-dependent endopeptidases responsible for degrading the extracellular matrix. They are also involved in cell proliferation, migration, differentiation and apoptosis. Most MMP’s are synthesised as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active. Their expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis. MMP-10 is a collagenase capable of degrading fibronectin, gelitins (types I, III, IV and V), and more weakly collagens III, IV and V. MMP-10 activates procollagenase.|
|Preservative & Stabilisers||0.05% Sodium Azide.|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human MMP-10 (Hinge Region) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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