|Application ||WB, IHC-P, E, Func|
|Calculated MW||14019 Da|
|Purification||Antiserum to human CXCL9 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Recombinant human CXCL9|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||C-X-C motif chemokine 9, Gamma-interferon-induced monokine, Monokine induced by interferon-gamma, HuMIG, MIG, Small-inducible cytokine B9, CXCL9, CMK, MIG, SCYB9|
|Target/Specificity||Rabbit anti-Human CXCL9 polyclonal antinbody recognizes human CXCL9, otherwise known as MIG (monokine induced by Interferon-gamma), a member of the CXC family of chemokine receptors, secreted by interferon stimulated monocytes, macrophages (Mulleret al.2010) and endothelial cells (Looset al.2006) CXCL9 signals through binding to CD183(CXCR3).CXCL9 acts as a Th1 (type 1 helper T) cell chemoattractant, and plays a role in the growth, activation and movement of cells associated with immune and inflammatory responses, and in tumour growth inhibition and angiogenesis (Whitinget al.2004) . Studies have shown that CXCL9 is active against E.coli, S.aureus, L.monocytogenes(Coleet al.2001) and S.pyogenes(Egestenet al.2007).|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Human CXCL9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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1. Ciccia, F. et al. (2014) Macrophage phenotype in the subclinical gut inflammation of patients with ankylosing spondylitis.Rheumatology (Oxford). 53 (1): 104-13.
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