|Application ||WB, IHC-P, E, Func|
|Calculated MW||14019 Da|
|Purification||Antiserum to human CXCL9 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Recombinant human CXCL9|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||C-X-C motif chemokine 9, Gamma-interferon-induced monokine, Monokine induced by interferon-gamma, HuMIG, MIG, Small-inducible cytokine B9, CXCL9, CMK, MIG, SCYB9|
|Target/Specificity||Rabbit anti-Human CXCL9 polyclonal antinbody recognizes human CXCL9, otherwise known as MIG (monokine induced by Interferon-gamma), a member of the CXC family of chemokine receptors, secreted by interferon stimulated monocytes, macrophages (Mulleret al.2010) and endothelial cells (Looset al.2006) CXCL9 signals through binding to CD183(CXCR3).CXCL9 acts as a Th1 (type 1 helper T) cell chemoattractant, and plays a role in the growth, activation and movement of cells associated with immune and inflammatory responses, and in tumour growth inhibition and angiogenesis (Whitinget al.2004) . Studies have shown that CXCL9 is active against E.coli, S.aureus, L.monocytogenes(Coleet al.2001) and S.pyogenes(Egestenet al.2007).|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Human CXCL9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Ciccia, F. et al. (2014) Macrophage phenotype in the subclinical gut inflammation of patients with ankylosing spondylitis.Rheumatology (Oxford). 53 (1): 104-13.
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