|Application ||WB, IHC-F|
|Calculated MW||133236 Da|
|Purification||Antisera to metabotropic glutamate receptor 1a were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Peptide corresponding to amino acids 1115-1130 from the C-terminal region of rat mGluR1a.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Metabotropic glutamate receptor 1, mGluR1, Grm1, Gprc1a, Mglur1|
|Target/Specificity||ABD11176 recognises rat metabotropic glutamate receptor 1a (mGluR1a). The metabotropic glutamate receptors have been organised into three groups. mGluR5 and mGluR1 make up group I which, when activated, stimulates phospholipase C and activates protein kinase C to hydrolyse phosphoinositide phospholipids in the cell membrane. Group I mGluRs, but not other groups, are activated by 3, 5-dihydroxyphenylglycine (DHPG).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 0.01% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Rat Metabotropic Glutamate Receptor 1a Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Copani, A et al. (2000) Reducing conditions differentially affect the functionaland structural properties of group-I and -II metabotropic glutamate receptors.Brain Res. 867: 165-172.
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