|Calculated MW||166071 Da|
|Purification||Antisera to rat NMDA receptor NR2B subunit were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Peptide from the N-terminus of the NR2B subunit of rat NMDA receptor.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Glutamate receptor ionotropic, NMDA 2B, GluN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B, Grin2b|
|Target/Specificity||ABD11178 recognises the NR2B subunit of the NMDA (N-methyl-D-aspartate) receptor.Receptors for NMDA belong to a group of ionotropic glutamate receptors which play a key role in the mediation of glutamate neurotransmission within the mammalian central nervous system (CNS), including involvement in memory and learning processes. Several antagonists and agonists of NMDA receptors (NMDAR) have been identified. Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage-dependent Mg2+ blockade and high Ca2+permeability.The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimer’s disease and also epilepsy and ischemic neuronal cell death.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 0.01% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Rat NMDA Receptor NR2B (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Chung, H.J. et al. (2004) Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand. J. Neurosci. 24: 10248-10259. 2. Popke, E.J. (2003) TOXOLOGICAL HIGHLIGHT: From anticholinesterase toxicity to Alzheimer’s disease: Important interactions of cholinergic and NMDA receptor systems. Toxological Sciences 72: 185-187.
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