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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-Mouse DACT1 Antibody    

Anti-Mouse DACT1 Antibody

Rabbit Anti-Mouse Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8R4A3
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 84306 Da
Additional Information
Purification Antisera to mouse Dact1 were raised by repeated immunisation of Rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen A peptide corresponding to amino acids 373-386 within exon4 of mouse Dact1.
Shelf Life 18 months from date of despatch.
Gene ID 59036
Other Names Dapper homolog 1, Dapper antagonist of catenin 1, Frodo homolog, MDpr1, Thymus-expressed novel gene 3 protein, Dact1, Thyex3
Target/Specificity Rabbit anti-Mouse DACT1 antibody recognizes mouse Dact1 (Dapper homolog 1), an intracellular protein and member of the dapper family, which acts as a positive regulator of the signalling pathways of Dishevelled 2 (DVL2), a cytoplasmic protein which plays a pivotal role in Wnt signalling during vertebrate development. Dact1 is involved in enhancement of the transcriptional activation of target genes of the Wnt signalling pathway, through its intracellular co-localization with DVL2 and inhibition of the degradation of CTNNB1/beta-catenin. Mice homozygous for mutations in Dact1, display malformations involving the spine, genitourinary system and distal digestive tract, which was traced to disrupted germ-layer morphogenesis at the primitive streak (Suriben, R. et al.).
Preservative & Stabilisers 0.02% Thiomersal
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse DACT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Suriben, R. et al. (2009) Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak.
Nat. Genet. 41: 977-985

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Cat# ABD11179
(40 western blots)
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