|Calculated MW||84306 Da|
|Purification||Antisera to mouse Dact1 were raised by repeated immunisation of Rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||A peptide corresponding to amino acids 373-386 within exon4 of mouse Dact1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Dapper homolog 1, Dapper antagonist of catenin 1, Frodo homolog, MDpr1, Thymus-expressed novel gene 3 protein, Dact1, Thyex3|
|Target/Specificity||Rabbit anti-Mouse DACT1 antibody recognizes mouse Dact1 (Dapper homolog 1), an intracellular protein and member of the dapper family, which acts as a positive regulator of the signalling pathways of Dishevelled 2 (DVL2), a cytoplasmic protein which plays a pivotal role in Wnt signalling during vertebrate development. Dact1 is involved in enhancement of the transcriptional activation of target genes of the Wnt signalling pathway, through its intracellular co-localization with DVL2 and inhibition of the degradation of CTNNB1/beta-catenin. Mice homozygous for mutations in Dact1, display malformations involving the spine, genitourinary system and distal digestive tract, which was traced to disrupted germ-layer morphogenesis at the primitive streak (Suriben, R. et al.).|
|Preservative & Stabilisers||0.02% Thiomersal|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse DACT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Suriben, R. et al. (2009) Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak.Nat. Genet. 41: 977-985
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