|Application ||WB, E|
|Calculated MW||35937 Da|
|Purification||Antiserum to human ANXA5 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||6xHis-tagged full-length recombinant human ANXA5 (NP_001145.1).|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Annexin A5, Anchorin CII, Annexin V, Annexin-5, Calphobindin I, CBP-I, Endonexin II, Lipocortin V, Placental anticoagulant protein 4, PP4, Placental anticoagulant protein I, PAP-I, Thromboplastin inhibitor, Vascular anticoagulant-alpha, VAC-alpha, ANXA5, ANX5, ENX2, PP4|
|Target/Specificity||Rabbit anti-Human Annexin V antibody (ABD11188) recognises human annexin V (ANXA5), otherwise known as lipocortin V, a calcium-dependent phospholipid-binding protein and member of the annexin family, which binds with high affinity and selectivity to phosphatidylserine (PS).The translocation of PS from the cytosolic leaflet to the outer leaflet of the plasma membrane, due to a loss in plasma membrane asymmetry during apoptosis, acts as an in vivo signal for the removal of the dying cell, by phagocytosis. Detection of PS using Annexin V therefore provides a reliable diagnostic tool for the indication of early programmed cell death. Annexin V has also been identified as an anticoagulant protein in the blood coagulation cascade, by acting as an inhibitor of prothrombin activation. The presence of antibodies to Annexin V, are associated with systemic lupus erythematosus, recurrent spontaneous abortions and systemic sclerosis.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Annexin V Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Moss, S.E. and Morgan, R. O. (2004) The annexins.Genome Biol. 5: 219-219.8
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