|Application ||WB, E|
|Calculated MW||46106 Da|
|Purification||Antiserum to human Beta arrestin-2 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide sequence C-HDHIPLPRPQS from the internal region of the ARRB2 near the C-terminus (aa 350-360) as indicated in UniProt entry: P32121.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Beta-arrestin-2, Arrestin beta-2, ARRB2, ARB2, ARR2|
|Target/Specificity||Goat anti-Human beta arrestin-2 antibody recognises human beta arrestin-2, a 409 amino acid ~45 kDa scaffold protein and member of the arrestin family, highly expressed in the central nervous system. Beta-arrestin-2 plays a role in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling, through receptor desensitization and internalization. Beta-arrestin-2 may function in the regulation of synaptic receptors, and in scaffold-linking GPCRs to JNK3, thereby enhancing the GPCR-mediated activation of JNK3, associated with cell apoptosis.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human beta Arrestin-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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