|Application ||WB, E|
|Calculated MW||57221 Da|
|Purification||Antiserum to human PTBP1 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide sequence DGIVPDIAVGTKR-C from the N-Terminal region of PTBP1 (NP_002810.1; NP_114367.1; NP_114368.1; NP_787041.1).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Polypyrimidine tract-binding protein 1, PTB, 57 kDa RNA-binding protein PPTB-1, Heterogeneous nuclear ribonucleoprotein I, hnRNP I, PTBP1, PTB|
|Target/Specificity||Goat anti-Human PTBP1 antibody; recognizes an epitope within the N-terminal (NT) region of human PTBP1, otherwise known as polypyrimidine tract-binding protein 1. PTPB1 is a multi-functional, ubiquitously expressed heterogeneous nuclear ribonucleoprotein (hnRNP), implicated in pre-mRNA processing, mRNA metabolism and transport. PTPB1 contains 4 RRMmotifs.PTBP1 is highly over-expressed in glioma and, along with its brain-specific homologue PTBP2, acts as a regulator of neural precursor cell differentiation (Zhanget al.2013). There are 3 described isoforms of PTPB1 derived by alternative splicing, isoforms differ in having insertions between the RRM domains 2 and 3. Goat anti-Human PTBP1 antibody is expected to recognize all isoforms of PTPB1.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human PTBP1 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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