|Application ||WB, E|
|Calculated MW||29634 Da|
|Purification||Antiserum to human DPM1 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide sequence RELEVRSPRQNKYS-C from the N-Terminal region of DPM1 (NP_003850.1).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Dolichol-phosphate mannosyltransferase subunit 1, 220.127.116.11, Dolichol-phosphate mannose synthase subunit 1, DPM synthase subunit 1, Dolichyl-phosphate beta-D-mannosyltransferase subunit 1, Mannose-P-dolichol synthase subunit 1, MPD synthase subunit 1, DPM1|
|Target/Specificity||ABD11221 specifically recognises an epitope within the N-terminal (NT) region of human DPM1, otherwise known as dolichol-phosphate mannosyltransferase, a member of the glycosyltransferase 2 family, expressed in the endoplasmic reticulum (ER).DPM1 is involved in the formation of dolichol phosphate mannose (Dol-P-Man), through the transfer of mannose from GDP-mannose to dolichol monophosphate. Dol-P-Man then acts as a mannosyl donor for protein N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation. Defects in DPM1 are responsible for the congenital disorder known as glycosylation type 1E (CDG1E), a metabolic deficiency in glycoprotein biosynthesis, resulting in severe mental and psychomotor retardation.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human DPM1 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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