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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-Human APH-1A Antibody    

Anti-Human APH-1A Antibody

Goat Anti-Human Polyclonal Antibody

  • WB - Anti-Human APH-1A Antibody  ABD11261
    Human Cerebral Cortex cell lysate probed with Goat anti Human APH-1A
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96BI3
Reactivity Human
Host Goat
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 28996 Da
Additional Information
Purification Antiserum to human APH-1A was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Immunogen Synthetic peptide sequence C-HVTDRSDARLQYG from the internal region of human APH-1A (NP_001071096.1; NP_057106.2).
Shelf Life 18 months from date of despatch.
Gene ID 51107
Other Names Gamma-secretase subunit APH-1A, APH-1a, Aph-1alpha, Presenilin-stabilization factor, APH1A, PSF
Target/Specificity Goat anti-Human APH-1A antibody recognises human APH-1A (gamma-secretase subunit APH-1A), otherwise known as anterior pharynx defective 1 homolog A, an integral transmembrane protein, and member of the APH-1 family, which is predominantly located in the endoplasmic reticulum and cis-Golgi, and is an essential component of the endoprotease gamma-secretase complex.The gamma-secretase complex, consisting of APH-1 (APH-1A or APH-1B), presenilin-1 or -2 (PSEN1 or PSEN2), nicastrin (NCSTN), and Pen-2 (PEN2), plays a vital role in the evolutionarily conserved Notch signaling pathway, by catalyzing the intramembrane S3 cleavage of ligand-activated Notch receptor proteins (Notch1-4), resulting in the generation and release of an activated NICD fragment, which then translocates to the nucleus and activates the transcription of downstream effector genes.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin;
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human APH-1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Hiramoto, K. & Kasahara, E. (2015) Long-term UVA eye irradiation causes decreased learning ability in mice.
Photodermatol Photoimmunol Photomed. Dec 10. [Epub ahead of print]

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Cat# ABD11261
(40 western blots)
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