|Application ||WB, E|
|Calculated MW||28996 Da|
|Purification||Antiserum to human APH-1A was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide sequence C-HVTDRSDARLQYG from the internal region of human APH-1A (NP_001071096.1; NP_057106.2).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Gamma-secretase subunit APH-1A, APH-1a, Aph-1alpha, Presenilin-stabilization factor, APH1A, PSF|
|Target/Specificity||Goat anti-Human APH-1A antibody recognises human APH-1A (gamma-secretase subunit APH-1A), otherwise known as anterior pharynx defective 1 homolog A, an integral transmembrane protein, and member of the APH-1 family, which is predominantly located in the endoplasmic reticulum and cis-Golgi, and is an essential component of the endoprotease gamma-secretase complex.The gamma-secretase complex, consisting of APH-1 (APH-1A or APH-1B), presenilin-1 or -2 (PSEN1 or PSEN2), nicastrin (NCSTN), and Pen-2 (PEN2), plays a vital role in the evolutionarily conserved Notch signaling pathway, by catalyzing the intramembrane S3 cleavage of ligand-activated Notch receptor proteins (Notch1-4), resulting in the generation and release of an activated NICD fragment, which then translocates to the nucleus and activates the transcription of downstream effector genes.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human APH-1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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1. Hiramoto, K. & Kasahara, E. (2015) Long-term UVA eye irradiation causes decreased learning ability in mice.Photodermatol Photoimmunol Photomed. Dec 10. [Epub ahead of print]
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