Anti-Human MAML1 (N-Terminal) Antibody
Goat Anti-Human Polyclonal Antibody
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- BACKGROUND
Application ![]()
| WB, E |
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Primary Accession | Q92585 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Isotype | Polyclonal IgG |
Calculated MW | 108054 Da |
Purification | Antiserum to human MAML1 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography. |
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Immunogen | Synthetic peptide sequence VLPTCPMAEFALPR from the N-Terminal region of MAML1 (NP_055572.1). |
Shelf Life | 18 months from date of despatch. |
Gene ID | 9794 |
Other Names | Mastermind-like protein 1, Mam-1, MAML1 (HGNC:13632) |
Target/Specificity | Rabbit anti-Human MAML1 antibody recognises an epitope within the N-Terminal (NT) region of human MAML1 (Mastermind-like Protein 1), a widely expressed nuclear protein and member of the mastermind family, which acts as a crucial coactivator of Notch-mediated transcriptional activation, and plays a role in hematopoietic development, by acting as a regulator of Notch-mediated lymphoid cell fate decisions. MAML1 interacts with the Mediator complex component CDK8 (Cyclin-dependent kinase 8), enhancing the phosphorylation and proteolytic turnover of the Notch intracellular domain (NICD) within the nucleus, and forms a DNA-binding complex with RBPSUH/RBP-J kappa/CBF1, playing a vital role in the transcriptional activation of Notch targets. Studies have shown that the NT region of MAML1 interacts with the DNA-binding domain of the tumor suppressor protein p53, and that over-expression of MAML1, greatly increases p53-mediated gene transcription and biological function. |
Preservative & Stabilisers | 0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin; |
Storage | Store at +4℃ or at -20 ℃. |
Precautions | Anti-Human MAML1 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Research Areas
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$ 413.00
Cat# ABD11263
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