|Application ||WB, IP|
|Calculated MW||132821 Da|
|Purification||Antiserum to human CCAR1 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to an epitope within amino acid residues 700-750 of human CCAR1(NP_060707.2).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Cell division cycle and apoptosis regulator protein 1, Cell cycle and apoptosis regulatory protein 1, CARP-1, Death inducer with SAP domain, CCAR1, CARP1, DIS|
|Target/Specificity||Rabbit anti-Human CCAR1 antibody recognises human CCAR1 (Cell cycle and apoptosis regulatory protein 1), a perinuclear phosphoprotein expressed by several epithelial cancer cell lines, which has been implicated as a regulator of transcription, through association with components of the Mediator and p160 coactivator complexes, and its role as a p53 coactivator. CCAR1 acts as an inducer of apoptosis signalling, under the regulation of the epidermal growth factor receptor (EGFR), caspase-9 activation, the mitogen-activated protein kinase pathway, and in response to chemotherapeutic agents, and has been shown to act as a suppressor of human breast cancer growth.|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CCAR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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