|Application ||WB, E|
|Calculated MW||62320 Da|
|Purification||Antiserum to human AMPK alpha 2 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide sequence CPLDALNTTKP from the internal region of AMPK alpha 2 (NP_006243.2).|
|Shelf Life||18 months from date of despatch.|
|Other Names||5'-AMP-activated protein kinase catalytic subunit alpha-2, AMPK subunit alpha-2, 18.104.22.168, Acetyl-CoA carboxylase kinase, ACACA kinase, 22.214.171.124, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, 126.96.36.199, PRKAA2, AMPK, AMPK2|
|Target/Specificity||ABD11265 specifically recognises AMPK alpha 2, otherwise known as PRKAA2, a Serine/threonine-protein kinase and the catalytic subunit of the AMP-activated protein kinase (AMPK), a central metabolic sensor, essential for the regulation of fatty acid and cholesterol synthesis, in response to fluctuations in nutrient and intracellular energy levels.AMPK has been implicated as a suppressor of cell proliferation of both normal and malignant cells, and recent studies have shown that the binding of AMPK to the PS domain of ULK1, is essential for ULK1-mediated autophagy, and that the phosphorylation of raptor by AMPK, plays an important role in autophagy induction.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human AMPK alpha 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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