|Application ||WB, IHC-P, E, IP, Func|
|Calculated MW||18086 Da|
|Purification||Antisera to human IL-15 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by antigen affinity chromatography.|
|Immunogen||Recombinant human IL-15|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Interleukin-15, IL-15, IL15|
|Target/Specificity||Rabbit anti-Human Interleukin-15 antibody recognizes human IL-15 (Interleukin-15), a 14kDa immunomodulatory glycoprotein expressed by multiple tissues and cell types, which primarily stimulates T lymphocytes, but is also critical for the development and activation of natural killer cells (NK).IL-15 shares functional properties with IL-2 and binds with high affinity to the IL-15 receptor (IL-15R), consisting of the IL-15R alpha chain, and also the IL-2Rbeta and common gamma chains used by the IL-2 receptor. Affects of IL-15 have been linked with cells and tissues unrelated to the immune system, and increased expression of IL-15 has been demonstrated in Rheumatoid Arthritis (RA), ulcerative colitis (UC) Chron’s disease (CD) and lymphoid malignancies, and also conditions affiliated with HIV and HTLV-1 infection.Rabbit anti-Human Interleukin-15 antibody will neutralise IL-15 activity in bioassay systems.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Human Interleukin-15 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Kurys, G. et al. (2000) The long signal peptide isoform and its alternative processing direct the intracellular trafficking of interleukin-15.J. Biol. Chem. 275: 30653 - 30659. 2. Fehniger, T.A. and Caligiuri, M.A. et al (2001) Interleukin 15: biology and relevance to human disease. BLOOD. 97: 14-32.
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