|Application ||WB, E|
|Calculated MW||23720 Da|
|Purification||Antisera to human GDNF were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Recombinant human GDNF|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Glial cell line-derived neurotrophic factor, hGDNF, Astrocyte-derived trophic factor, ATF, GDNF|
|Target/Specificity||Rabbit anti-Human GDNF antibody recognizes human GDNF (Glial cell line-derived growth factor), a glycosylated, disulfide-bonded homodimer which shares structural homology with Persephin, Artemin and Neurturin and has been identified as specifically promoting the uptake of dopamine, and consequently the survival and function, of midbrain dopamine (DA) neurons.The ability of GDNF to promote the development of DA neurons in the brain has become a focus area for studies into Parkinsons disease, which is itself characterised by the progressive degeneration of midbrain DA neurons (Granholmet al.2000).|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Human GDNF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Lin, L.F. et al. (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science. 260: 1130-1132. 2. Granholm, A-C. et al. (2000) Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons. J. Neurosci. 20: 3182-3190.
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