|Calculated MW||28617 Da|
|Purification||Antisera to Dynorphin B (1-13) were raised by repeated immunisation of rabbits with highly purified antigen.|
|Immunogen||Synthetic peptide, YGGFLRRQFKVVT, corresponding to full-length porcine dynorphin B (1-13), conjugated to thyroglobulin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Proenkephalin-B, Beta-neoendorphin-dynorphin, Preprodynorphin, Alpha-neoendorphin, Beta-neoendorphin, Big dynorphin, Big Dyn, Dynorphin A(1-17), Dyn-A17, Dynorphin A, Dynorphin A(1-13), Dynorphin A(1-8), Leu-enkephalin, Rimorphin, Dynorphin B, Dyn-B, Dynorphin B(1-13), Leumorphin, Dynorphin B-29, PDYN|
|Target/Specificity||Rabbit anti-Dynorphin B antibody recognizes dynorphin B, an endogenous opioid peptide, also known as rimorphin with the peptide sequence Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr, derived from the sequential cleavage of pro-enkephalin B to form leumorphin which is, in turn cleaved to form dynorphin B (Devi et al. 1985). The cleavage of the dynorphin precursors to form the dynorphin neuropeptides is largely controlled by the serine protease cathepsin L which co-localizes with dynorphins in secretory vesicles of brain cortical neurons(Funkelstein et al. 2010) and prohormone convertase 2, a member of the furin, peptidate S8 family (Schwarzer 2009).Dynorphin b sequence is well conserved among mammal, avian (Youngrenet al.1993) and reptilian (Goldsmithet al. 1992) species. Rabbit anti-Dynorphin b antibody is expected to have a wide species cross reactivity.|
|Preservative & Stabilisers||0.09% Sodium Azide; 1% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Dynorphin B (aa1-13) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Khachaturinan, H., Lewis, M.E., Haber, S.N., Houghten, R.A., Akil, H. and Watson, S.J. (1985) Pro-Dynorphin peptide immunocytochemistry in rhesus monkey brain.Peptides 6 (Suppl.2): 155-166. 2. Sherman, T.G. et al. (1988) Regulation of hypothalamic magnocellular neuropeptides and their mRNAs in the Brattleboro rat: coordinate responses to further osmotic challengeJ. Neuroscience 8: 3785 - 3796 3. Neal, C.R. and Newman, S.W. (1989) Prodynorphin Peptide Distribution in the Forebrain of the Syrian Hamster and Rat: A Comparative Study with Antisera Against Dynorphin A, Dynorphin B, and the C-Terminus of the Prodynorphin Precursor Molecule.J. Comp. Neurology 288: 353-386. 4. Zhang, L. et al. (2004) Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors.J Neurosci. 24: 3344-54. 5. Darmopil, S. et al. (2009) Genetic inactivation of dopamine D1 but not D2 receptors inhibits L-DOPA-induced dyskinesia and histone activation.Biol Psychiatry. 66: 603-13. 6. Ruiz-DeDiego, I. et al. (2014) Activation of DREAM (Downstream Regulatory Element Antagonistic Modulator), a Calcium-Binding Protein, Reduces L-DOPA-Induced Dyskinesias in Mice.Biol Psychiatry. pii: S0006-3223(14)00224-8.
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