|Calculated MW||28079 Da|
|Purification||Antisera to Leumorphin were raised by repeated immunisation of rabbits with highly purified antigen. Whole serum is supplied - diluted.|
|Immunogen||Leumorphin: Arg-Ser-Gln-Glu-Asn-Pro-Asn-Thr-Tyr-Ser-Glu-Asp-Leu-Asp-Val (rat 14-28)|
|Shelf Life||18 months from date of despatch.|
|Other Names||Proenkephalin-B, Beta-neoendorphin-dynorphin, Preprodynorphin, Alpha-neoendorphin, Beta-neoendorphin, Big dynorphin, Big Dyn, Dynorphin A(1-17), Dyn-A17, Dynorphin A, Dynorphin A(1-13), Dynorphin A(1-8), Leu-enkephalin, Rimorphin, Dynorphin B, Dyn-B, Dynorphin B(1-13), Leumorphin, Dynorphin B-29, Pdyn|
|Target/Specificity||Rabbit anti-Leumorphin antibody recognizes rat leumorphin, also known as dynorphin B29. Leumorphin is a 28 amino acid opioid peptide resulting from cleavage of proenkephalin-B. Leumorphin positive cells are found in the paraventricular, supraoptic nucleus and fibres in the lateral hypothalamus of colchicine treated rat brain (Neal & Newman 1989). Leumorphin has been reported to exert anti-apoptotic effects in rat PC12 pheochromocytoma cells (Leeet al.2005).Rabbit anti-leumorphin has been used successfully to detect leumorphin in murine brain using immunohistochemistry on cryostat sections.(Zhanget al.2005).|
|Preservative & Stabilisers||0.09% Sodium Azide; 1% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Leumorphin Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Drake, C.T. et al. (1994) Dynorphin opioids present in dentate granule cells may function as retrograde inhibitory neurotransmitters.J. Neuroscience 14: 3736-3750. 2. Xu, M. et al. (1994) Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses.Cell 79: 729-742. 3. Neal, C.R. and Newman, S.W. (1989) Prodynorphin Peptide Distribution in the Forebrain of the Syrian Hamster and Rat: A Comparative Study with Antisera Against Dynorphin A, Dynorphin B and The C-Terminus of the Prodynorphin Precursor Molecule. .J. Comp. Neurology 288: 353-386 4. Zhang, D. et al. (2005) Repeated cocaine administration induces gene expression changes through the dopamine D1 receptors.Neuropsychopharmacology. 30: 1443-54. 5. Zhang, J. et al. (2006) c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes.J Neurosci. 26: 13287-96.
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