|Calculated MW||301367 Da|
|Purification||Antisera to human ATR peptide were raised by repeated immunisation of rabbits with highly purified antigen.|
|Immunogen||Human ATR peptide, amino acids 2381-2644|
|Shelf Life||18 months from date of despatch.|
|Other Names||Serine/threonine-protein kinase ATR, 22.214.171.124, Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1, ATR, FRP1|
|Target/Specificity||ABD11292 recognises the ATR (Ataxia telangiectasia and rad 3 related) protein, a 300kD protein kinase reported to have a role in recognising and responding to DNA strand interruptions during meiosis.ABD11292 cross-reacts with the related DNA-Pkcs.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-ATR (aa2381-2644) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Keegan, K.S. et al. (1996) The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.Genes and Development 10: 2423-2437. 2. McNees, C.J. et al. (2010) ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase.J. Cell Biol. 188: 639-52 3. Yan, T. et al. (2004) CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.Mol Cancer Ther. 3: 1147-57. 4. Cuadrado, M. et al. (2006) ATM regulates ATR chromatin loading in response to DNA double-strand breaks.J Exp Med. 203: 297-303. 5. Zinkel, S.S. et al. (2005) A role for proapoptotic BID in the DNA-damage response.Cell. 122: 579-91. 6. Murga, M. et al. (2009) A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging.Nat Genet. 41: 891-8. 7. Lewis, K.A. et al. (2005) Heterozygous ATR Mutations in Mismatch Repair–Deficient Cancer Cells Have Functional SignificanceCancer Res. 65: 7091-5. 8. Pontano, L.L. et al. (2008) Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability.Mol Cell Biol. 28: 7245-58. 9. Brown, E.J. and Baltimore, D. (2003) Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance.Genes Dev. 17: 615-28. 10. Park, B.J. et al. (2006) AIMP3 haploinsufficiency disrupts oncogene-induced p53 activation and genomic stability.Cancer Res. 66: 6913-8. 11. López-Contreras, A.J. et al. (2012) An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation.J Exp Med. 209 (3): 455-61.
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